Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms.

Inhibition of plasmin-mediated TAFI activation may affect development but not progression of abdominal aortic aneurysms.

<h4>Objective</h4>Thrombin-activatable fibrinolysis inhibitor (TAFI) reduces the breakdown of fibrin clots through its action as an indirect inhibitor of plasmin. Studies in TAFI-deficient mice have implicated a potential role for TAFI in Abdominal Aortic Aneurysm (AAA) disease. The role...

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Main Authors: Katherine Bridge, Charlotte Revill, Fraser Macrae, Marc Bailey, Nadira Yuldasheva, Stephen Wheatcroft, Roger Butlin, Richard Foster, D Julian Scott, Ann Gils, Robert Ariens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0177117&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0177117&type=printable

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