Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon Pseudomonas aeruginosa infection

Human CFTR deficient iPSC-macrophages reveal impaired functional and transcriptomic response upon Pseudomonas aeruginosa infection

IntroductionCystic fibrosis (CF) is a hereditary autosomal recessive disease driven by deleterious variants of the CFTR gene, leading, among other symptoms, to increased lung infection susceptibility. Mucus accumulation in the CF lung is, as of yet, considered as one important factor contributing to...

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Main Authors: Claudio Rodriguez Gonzalez, Débora Basílio-Queirós, Anna-Lena Neehus, Sylvia Merkert, David Tschritter, Sinem Ünal, Jan Hegermann, Matthias Mörgelin, Jacinta Bustamante, Manuel Manfred Nietert, Ulrich Martin, Burkhard Tümmler, Antje Munder, Nico Lachmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
cystic fibrosis
macrophages
iPSC
infection
Pseudomonas aeruginosa
lung immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1397886/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1397886/full

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