Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa

Two highly selected mutations in the tandemly duplicated CYP6P4a and CYP6P4b genes drive pyrethroid resistance in Anopheles funestus in West Africa

Abstract Background Gaining a comprehensive understanding of the genetic mechanisms underlying insecticide resistance in malaria vectors is crucial for optimising the effectiveness of insecticide-based vector control methods and developing diagnostic tools for resistance management. Considering the...

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Main Authors: Nelly M. T. Tatchou-Nebangwa, Leon M. J. Mugenzi, Abdullahi Muhammad, Derrick N. Nebangwa, Mersimine F. M. Kouamo, Carlos S. Djoko Tagne, Theofelix A. Tekoh, Magellan Tchouakui, Stephen M. Ghogomu, Sulaiman S. Ibrahim, Charles S. Wondji
Format: Article
Language:English
Published: BMC 2024-12-01
Series:BMC Biology
Subjects:
Anopheles funestus
Insecticide resistance
Cytochrome P450
Insecticide metabolism assay
Heterologous expression
GAL4/UAS expression
Online Access:https://doi.org/10.1186/s12915-024-02081-y
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https://doi.org/10.1186/s12915-024-02081-y

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