Eight induced pluripotent stem cell lines (iPSCs) derived from two patients with Leukocyte adhesion deficiency Type I (LAD I) with mutations in the ITGB2 gene

Eight induced pluripotent stem cell lines (iPSCs) derived from two patients with Leukocyte adhesion deficiency Type I (LAD I) with mutations in the ITGB2 gene

Leukocyte Adhesion Deficiency Type I (LAD I) is a rare inborn error of immunity caused by mutations in the ITGB2 gene coding for β2-integrin CD18 on the surface of leukocytes. Affected patients display severe clinical manifestations with life threatening infections and inflammatory complications due...

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Main Authors: Julia Fekadu-Siebald, Nina V Fuchs, Stella Zahn, Marcel G E Rommel, Franziska Schenk, Sabine Huenecke, Melanie Bremm, Hermann Kreyenberg, Zyrafete Kuci, Eva-Maria Jacobsen, Manfred Hoenig, Klaus Schwarz, Peter Bader, Ute Modlich, Renate König, Shahrzad Bakhtiar
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Stem Cell Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1873506124002964
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