Design, synthesis, and biological evaluation of substituted benzyl-triazolopyridine derivatives as non-hydroxamate based HDAC8 inhibitors

Design, synthesis, and biological evaluation of substituted benzyl-triazolopyridine derivatives as non-hydroxamate based HDAC8 inhibitors

Traditional Histone deacetylase 8 (HDAC8) inhibitors primarily rely on hydroxamate-based scaffolds. However, there is a growing interest in developing non-hydroxamate inhibitors to overcome potential limitations with hydroxamate-based inhibitors. In this study, we report the design, synthesis, and e...

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Bibliographic Details
Main Authors: N.V.M. Rao Bandaru, Ashna Fathima, Vandana Joshi, Markus Schweipert, Obanna Pathur, Kosana Sai Chaitanya, Trinath Jamma, Vivek Sharma, Chandrasekhar Abbineni, Franz-Josef Meyer-Almes, Kondapalli Venkata Gowri Chandra Sekhar
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
Histone deacetylase
Benzyl-1,2,4-triazolo[4,3-a] pyridine
Inhibitors
Anti-proliferative
Docking
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417425000111
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