Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.

Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2.

<h4>Background</h4>Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR) of the receptor, which conta...

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Main Authors: Wendy R Gordon, Didem Vardar-Ulu, Sarah L'Heureux, Todd Ashworth, Michael J Malecki, Cheryll Sanchez-Irizarry, Debbie G McArthur, Gavin Histen, Jennifer L Mitchell, Jon C Aster, Stephen C Blacklow
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-08-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006613&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0006613&type=printable

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