The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism

The N‐terminal domain of gasdermin D induces liver fibrosis by reprogrammed lipid metabolism

Abstract Background The emerging incidence of pathogenic liver conditions is turning into a major concern for global health. Induction of pyroptosis in hepatocytes instigates cellular disintegration, which in turn liberates substantial quantities of pro‐inflammatory intracellular substances, thereby...

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Bibliographic Details
Main Authors: Xue Wang, Chunyou Ning, Xingyi Cheng, Zhengzhong Wu, Dongbo Wu, Xuemei Ding, Cunxiang Ju, Zhihang Zhou, Lingfeng Wan, Wei Zhao, Peiliang Shi
Format: Article
Language:English
Published: Wiley 2025-01-01
Series:Animal Models and Experimental Medicine
Subjects:
GSDMD‐NT
lipid metabolism
liver fibrosis
NASH
pyroptosis
Online Access:https://doi.org/10.1002/ame2.12506
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https://doi.org/10.1002/ame2.12506

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