The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study
Objectives. Obstructive sleep apnoea (OSA) is associated with an increased risk of cardiovascular disease, with alterations in coagulability suspected as the mediating factor. This study explored blood coagulability and breathing-related parameters during sleep in patients with OSA. Design. Cross-se...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Clinical Practice |
| Online Access: | http://dx.doi.org/10.1155/2023/5817644 |
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| author | Jundong Yang Wenjun Xue Zhicheng Wei Caiqiong Hou Huaming Zhu Huajun Xu Xiaolin Wu Yunhai Feng Xinyi Li |
| author_facet | Jundong Yang Wenjun Xue Zhicheng Wei Caiqiong Hou Huaming Zhu Huajun Xu Xiaolin Wu Yunhai Feng Xinyi Li |
| author_sort | Jundong Yang |
| collection | DOAJ |
| description | Objectives. Obstructive sleep apnoea (OSA) is associated with an increased risk of cardiovascular disease, with alterations in coagulability suspected as the mediating factor. This study explored blood coagulability and breathing-related parameters during sleep in patients with OSA. Design. Cross-sectional observational study. Setting. Shanghai Sixth People’s Hospital. Participants. 903 patients diagnosed by standard polysomnography. Main Outcome and Measures. The relationships between coagulation markers and OSA were evaluated using Pearson’s correlation, binary logistic regression, and restricted cubic spline (RCS) analyses. Results. The platelet distribution width (PDW) and activated partial thromboplastin time (APTT) decreased significantly with increasing OSA severity (both p<0.001). PDW was positively associated with the apnoea-hypopnea index (AHI), oxygen desaturation index (ODI), and microarousal index (MAI) (ß = 0.136, p<0.001; ß = 0.155, p<0.001; and ß = 0.091, p=0.008, respectively). APTT was negatively correlated with AHI (ß = −0.128, p<0.001) and ODI (ß = −0.123, p=0.001). PDW was negatively correlated with percentage of sleep time with oxygen saturation below 90%(CT90) (ß = −0.092, p=0.009). The minimum arterial oxygen saturation (SaO2) correlated with PDW (ß = −0.098, p=0.004), APTT (ß = 0.088, p=0.013), and prothrombin time (PT) (ß = 0.106, p=0.0003). ODI was risk factors for PDW abnormalities (odds ratio (OR) = 1.009, p=0.009) after model adjustment. In the RCS, a nonlinear dose-effect relationship was demonstrated between OSA and the risk of PDW and APTT abnormalities. Conclusion. Our study revealed nonlinear relationships between PDW and APTT, and AHI and ODI, in OSA, with AHI and ODI increasing the risk of an abnormal PDW and thus also the cardiovascular risk. This trial is registered with ChiCTR1900025714. |
| format | Article |
| id | doaj-art-bd76f7eff0bd4fd590260e5e062e6ef8 |
| institution | Kabale University |
| issn | 1742-1241 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Clinical Practice |
| spelling | doaj-art-bd76f7eff0bd4fd590260e5e062e6ef82025-02-03T06:47:30ZengWileyInternational Journal of Clinical Practice1742-12412023-01-01202310.1155/2023/5817644The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational StudyJundong Yang0Wenjun Xue1Zhicheng Wei2Caiqiong Hou3Huaming Zhu4Huajun Xu5Xiaolin Wu6Yunhai Feng7Xinyi Li8Central Laboratory of Shanghai Eighth People’s Hospital Affiliated to Jiangsu UniversityDepartment of Otorhinolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep MedicineBasic Medical CollegeDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep MedicineDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep MedicineCentral Laboratory of Shanghai Eighth People’s Hospital Affiliated to Jiangsu UniversityDepartment of Otorhinolaryngology Head and Neck SurgeryDepartment of Otolaryngology Head and Neck Surgery & Center of Sleep MedicineObjectives. Obstructive sleep apnoea (OSA) is associated with an increased risk of cardiovascular disease, with alterations in coagulability suspected as the mediating factor. This study explored blood coagulability and breathing-related parameters during sleep in patients with OSA. Design. Cross-sectional observational study. Setting. Shanghai Sixth People’s Hospital. Participants. 903 patients diagnosed by standard polysomnography. Main Outcome and Measures. The relationships between coagulation markers and OSA were evaluated using Pearson’s correlation, binary logistic regression, and restricted cubic spline (RCS) analyses. Results. The platelet distribution width (PDW) and activated partial thromboplastin time (APTT) decreased significantly with increasing OSA severity (both p<0.001). PDW was positively associated with the apnoea-hypopnea index (AHI), oxygen desaturation index (ODI), and microarousal index (MAI) (ß = 0.136, p<0.001; ß = 0.155, p<0.001; and ß = 0.091, p=0.008, respectively). APTT was negatively correlated with AHI (ß = −0.128, p<0.001) and ODI (ß = −0.123, p=0.001). PDW was negatively correlated with percentage of sleep time with oxygen saturation below 90%(CT90) (ß = −0.092, p=0.009). The minimum arterial oxygen saturation (SaO2) correlated with PDW (ß = −0.098, p=0.004), APTT (ß = 0.088, p=0.013), and prothrombin time (PT) (ß = 0.106, p=0.0003). ODI was risk factors for PDW abnormalities (odds ratio (OR) = 1.009, p=0.009) after model adjustment. In the RCS, a nonlinear dose-effect relationship was demonstrated between OSA and the risk of PDW and APTT abnormalities. Conclusion. Our study revealed nonlinear relationships between PDW and APTT, and AHI and ODI, in OSA, with AHI and ODI increasing the risk of an abnormal PDW and thus also the cardiovascular risk. This trial is registered with ChiCTR1900025714.http://dx.doi.org/10.1155/2023/5817644 |
| spellingShingle | Jundong Yang Wenjun Xue Zhicheng Wei Caiqiong Hou Huaming Zhu Huajun Xu Xiaolin Wu Yunhai Feng Xinyi Li The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study International Journal of Clinical Practice |
| title | The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study |
| title_full | The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study |
| title_fullStr | The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study |
| title_full_unstemmed | The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study |
| title_short | The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study |
| title_sort | associations of platelet activation and coagulation parameters with obstructive sleep apnoea a large scale observational study |
| url | http://dx.doi.org/10.1155/2023/5817644 |
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