Aspalathin-rich unfermented Aspalathus linearsis extract mitigates vascular endothelial inflammation by inhibiting the TNF-α/Hexokinase 2/NF-κB signaling pathway

Aspalathin-rich unfermented Aspalathus linearsis extract mitigates vascular endothelial inflammation by inhibiting the TNF-α/Hexokinase 2/NF-κB signaling pathway

Inflammation of vascular endothelium initiates cardiovascular diseases. We investigated if unfermented green Aspalathus linearis (rooibos) extract (GRT) and its main flavonoid aspalathin may suppress inflammation in cardiovascular endothelial cells. Human coronary artery endothelial cells (HCAEC) an...

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Bibliographic Details
Main Authors: Ya-Pei Wang, Bi-Juan Wang, Hsin-Ying Lu, Christo J.F. Muller, Ying-Yu Kuo, Chieh Huo, Chih-Jen Lai, Shih-Han Huang, Elizabeth Joubert, Chih-Pin Chuu
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Journal of Agriculture and Food Research
Subjects:
Aspalathus linearis
Aspalathin
Vascular endothelial cells
NF-κB
HK2
Inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666154325002534
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