Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range

Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range

Abstract Cellular signal transduction is governed by multiple feedback mechanisms to elicit robust cellular decisions. The specific contributions of individual feedback regulators, however, remain unclear. Based on extensive time‐resolved data sets in primary erythroid progenitor cells, we establish...

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Bibliographic Details
Main Authors: Julie Bachmann, Andreas Raue, Marcel Schilling, Martin E Böhm, Clemens Kreutz, Daniel Kaschek, Hauke Busch, Norbert Gretz, Wolf D Lehmann, Jens Timmer, Ursula Klingmüller
Format: Article
Language:English
Published: Springer Nature 2011-07-01
Series:Molecular Systems Biology
Subjects:
apoptosis
erythropoietin
mathematical modeling
negative feedback
SOCS
Online Access:https://doi.org/10.1038/msb.2011.50
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https://doi.org/10.1038/msb.2011.50

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