Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors

Relaxin-2-secreting CAR-T cells exhibit enhanced efficacy in stromal-rich xenograft tumors

IntroductionChimeric antigen receptor (CAR)-T cell therapy has demonstrated notable efficacy in treating hematological malignancies. Although it has shown promise in the clinical management of solid tumors, poor outcomes in clinical trials highlight the challenges in developing therapies suitable fo...

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Bibliographic Details
Main Authors: Hisataka Ogawa, Tomoya Ekawa, Yu Mizote, Takashi Akazawa, Hideaki Tahara
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
chimeric antigen receptor T cell
pancreatic cancer
solid tumor
tumor stroma
relaxin-2
fibrosis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1506204/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1506204/full

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