The reovirus variant RP116 is oncolytic in immunocompetent models and generates reduced neutralizing antibodies to Type 3 Dearing

The reovirus variant RP116 is oncolytic in immunocompetent models and generates reduced neutralizing antibodies to Type 3 Dearing

The mammalian reovirus Type 3 Dearing (T3D) is a naturally occurring oncolytic virus. We previously identified a T3D variant isolated from persistently infected cancer cells that has a premature stop codon mutation in the S1 gene, generating a truncated σ1-attachment protein that lacks the globular...

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Bibliographic Details
Main Authors: Ki-Hoon Song, Xiao Xiang, So Hyun Lee, Jong Kyu Woo, Gansukh Enkhtaivan, Carlos Rios Giraldo, You-Rim Lee, Yeo Jin Jeong, Salar Pashangzadeh, Negar Sharifi, An-Dao Yang, Huy-Dung Hoang, Nam-Hyuk Cho, Yeon-Sook Lee, Dong Guk Park, Tommy Alain
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
reovirus variant
truncated Sigma1
determinant for reovirus oncolysis
ICI combination
reduction of neutralization
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000882
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