Routine malaria vaccination in Africa: a step toward malaria eradication?
Abstract Malaria remains a significant global health challenge, with nearly half of the world's population at risk of infection. In 2022 alone, malaria claimed approximately 608,000 lives, with 76% of these fatalities occurring in children under the age of five, underscoring the disease’s dispr...
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BMC
2025-01-01
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| Series: | Malaria Journal |
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| Online Access: | https://doi.org/10.1186/s12936-024-05235-z |
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| author | Olivier Sibomana John Bukuru Sulymon A. Saka Marie Grace Uwizeyimana Alex Mwangi Kihunyu Abraham Obianke Samuel Oluwo Damilare Lewis Tem Bueh Beloved of God Agbelemoge Richard Omoefe Oveh |
| author_facet | Olivier Sibomana John Bukuru Sulymon A. Saka Marie Grace Uwizeyimana Alex Mwangi Kihunyu Abraham Obianke Samuel Oluwo Damilare Lewis Tem Bueh Beloved of God Agbelemoge Richard Omoefe Oveh |
| author_sort | Olivier Sibomana |
| collection | DOAJ |
| description | Abstract Malaria remains a significant global health challenge, with nearly half of the world's population at risk of infection. In 2022 alone, malaria claimed approximately 608,000 lives, with 76% of these fatalities occurring in children under the age of five, underscoring the disease’s disproportionate impact on vulnerable populations. Africa bears the highest burden, accounting for 94% of global malaria cases. For over 60 years, the development of a malaria vaccine has been a critical objective for scientists and governments, with substantial efforts directed toward this goal. Recent progress has led to the approval of the first malaria vaccines, RTS,S/AS01 (Mosquirix®) and the R21/Matrix-M vaccine. Inspired by the promise of these vaccines, the global malaria community has renewed its focus on malaria eradication, 50 years after flawed earlier eradication efforts in the mid-twentieth century. Since the World Health Organization’s endorsement of RTS,S in 2021 and R21 in 2023, several African countries, beginning with Cameroon, have integrated these vaccines into routine immunization programmes. This review examines the role of routine malaria vaccination in Africa as a key strategy toward malaria elimination, explores challenges and solutions for widespread vaccine implementation, and discusses future directions in the ongoing fight to eliminate malaria on the continent. |
| format | Article |
| id | doaj-art-bd378eceb4f347088838cbfef66668ec |
| institution | Kabale University |
| issn | 1475-2875 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Malaria Journal |
| spelling | doaj-art-bd378eceb4f347088838cbfef66668ec2025-01-12T12:08:55ZengBMCMalaria Journal1475-28752025-01-012411910.1186/s12936-024-05235-zRoutine malaria vaccination in Africa: a step toward malaria eradication?Olivier Sibomana0John Bukuru1Sulymon A. Saka2Marie Grace Uwizeyimana3Alex Mwangi Kihunyu4Abraham Obianke5Samuel Oluwo Damilare6Lewis Tem Bueh7Beloved of God Agbelemoge8Richard Omoefe Oveh9Department of General Medicine and Surgery, College of Medicine and Health Sciences, University of RwandaDepartment of ENT, Rwanda Military Referral and Teaching HospitalDepartment of Otolaryngology, Irrua Specialist Teaching HospitalDepartment of General Medicine and Surgery, College of Medicine and Health Sciences, University of RwandaDepartment of Medicine and Surgery, College of Health Sciences, University of NairobiDepartment of Medicine and Surgery, College of Medical Sciences, Faculty of Clinical Science, Ambrose Alli UniversityDepartment of Dentistry and Dental Surgery, College of Medicine, University of IbadanDepartment of Computer Engineering, University of BueaDepartment of Medicine and Surgery, Ambrose Alli University EkpomaDepartment of Information and Communication Technology, Faculty of Computing, University of DeltaAbstract Malaria remains a significant global health challenge, with nearly half of the world's population at risk of infection. In 2022 alone, malaria claimed approximately 608,000 lives, with 76% of these fatalities occurring in children under the age of five, underscoring the disease’s disproportionate impact on vulnerable populations. Africa bears the highest burden, accounting for 94% of global malaria cases. For over 60 years, the development of a malaria vaccine has been a critical objective for scientists and governments, with substantial efforts directed toward this goal. Recent progress has led to the approval of the first malaria vaccines, RTS,S/AS01 (Mosquirix®) and the R21/Matrix-M vaccine. Inspired by the promise of these vaccines, the global malaria community has renewed its focus on malaria eradication, 50 years after flawed earlier eradication efforts in the mid-twentieth century. Since the World Health Organization’s endorsement of RTS,S in 2021 and R21 in 2023, several African countries, beginning with Cameroon, have integrated these vaccines into routine immunization programmes. This review examines the role of routine malaria vaccination in Africa as a key strategy toward malaria elimination, explores challenges and solutions for widespread vaccine implementation, and discusses future directions in the ongoing fight to eliminate malaria on the continent.https://doi.org/10.1186/s12936-024-05235-zMalariaVaccineEliminationAfrica |
| spellingShingle | Olivier Sibomana John Bukuru Sulymon A. Saka Marie Grace Uwizeyimana Alex Mwangi Kihunyu Abraham Obianke Samuel Oluwo Damilare Lewis Tem Bueh Beloved of God Agbelemoge Richard Omoefe Oveh Routine malaria vaccination in Africa: a step toward malaria eradication? Malaria Journal Malaria Vaccine Elimination Africa |
| title | Routine malaria vaccination in Africa: a step toward malaria eradication? |
| title_full | Routine malaria vaccination in Africa: a step toward malaria eradication? |
| title_fullStr | Routine malaria vaccination in Africa: a step toward malaria eradication? |
| title_full_unstemmed | Routine malaria vaccination in Africa: a step toward malaria eradication? |
| title_short | Routine malaria vaccination in Africa: a step toward malaria eradication? |
| title_sort | routine malaria vaccination in africa a step toward malaria eradication |
| topic | Malaria Vaccine Elimination Africa |
| url | https://doi.org/10.1186/s12936-024-05235-z |
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