Nonproductive exposure of PBMCs to SARS‐CoV‐2 induces cell‐intrinsic innate immune responses

Nonproductive exposure of PBMCs to SARS‐CoV‐2 induces cell‐intrinsic innate immune responses

Abstract Cell‐intrinsic responses mounted in PBMCs during mild and severe COVID‐19 differ quantitatively and qualitatively. Whether they are triggered by signals emitted by productively infected cells of the respiratory tract or result from physical interaction with virus particles remains unclear....

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Main Authors: Julia Kazmierski, Kirstin Friedmann, Dylan Postmus, Jackson Emanuel, Cornelius Fischer, Jenny Jansen, Anja Richter, Laure Bosquillon de Jarcy, Christiane Schüler, Madlen Sohn, Sascha Sauer, Christian Drosten, Antoine‐Emmanuel Saliba, Leif Erik Sander, Marcel A Müller, Daniela Niemeyer, Christine Goffinet
Format: Article
Language:English
Published: Springer Nature 2022-08-01
Series:Molecular Systems Biology
Subjects:
interferon
interferon‐stimulated genes
PBMCs
SARS‐CoV‐2
Online Access:https://doi.org/10.15252/msb.202210961
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https://doi.org/10.15252/msb.202210961

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