Dual functions of silibinin in attenuating aortic dissection via regulating iron homeostasis and endoplasmic reticulum stress against ferroptosis

Dual functions of silibinin in attenuating aortic dissection via regulating iron homeostasis and endoplasmic reticulum stress against ferroptosis

Abstract Aortic dissection (AD) poses a significant threat to cardiovascular health globally, yet its underlying mechanisms remain elusive. Smooth muscle cells death and phenotypic switching are critically important pathological processes in AD. Currently, no pharmacological therapies have proven ef...

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Main Authors: Zhen Qi, Qiu-Guo Wang, Meng-Xi Huang, Yi-Fan Zeng, Jing-Yu Li, Zhi-Cheng Duan, Ling Tan, Hao Tang
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07309-x
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https://doi.org/10.1038/s41419-024-07309-x

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