Clinical relevance and druggability of sole reciprocal kinase fusions: A large‐scale study

Clinical relevance and druggability of sole reciprocal kinase fusions: A large‐scale study

Abstract Background Building on our prior work that RNA alternative splicing modulates the druggability of kinase fusions, this study probes the clinical significance of sole reciprocal fusions. These rare genomic arrangements, despite lacking kinase domains at the DNA level, demonstrated potential...

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Main Authors: Jiao Feng, Tonghui Ma, Chunyang Wang, Baoming Wang, Qian Liu, Zhengchuang Liu, Houquan Tao, Zaiyuan Ye
Format: Article
Language:English
Published: Wiley 2024-09-01
Series:Cancer Medicine
Subjects:
NGS
sequencing
sole reciprocal
targeted therapy
tumor
Online Access:https://doi.org/10.1002/cam4.70191
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https://doi.org/10.1002/cam4.70191

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