Evaluation of Ototoxic Effects of Cisplatin in a Rat Model: A Dose–Response Study

Evaluation of Ototoxic Effects of Cisplatin in a Rat Model: A Dose–Response Study

Cisplatin (cis-diclorodiamminoplatin, CDDP) is a common chemotherapeutic agent for solid tumors, but its use is limited by severe side effects such as ototoxicity and nephrotoxicity. Variability in CDDP dosing and administration, along with high mortality and sensitivity in animal models, complicate...

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Main Authors: Filippo Hellies, Silvia Fracaro, Giovanni Pintus, Edi Simoni, Erica Gentilin, Gino Marioni, Alessandro Martini, Piero Nicolai, Elisabetta Zanoletti, Giovanna Albertin, Laura Astolfi
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Applied Sciences
Subjects:
auditory brainstem response
drug toxicity
acute kidney injury
ototoxicity
oxidative stress
hair cells
Online Access:https://www.mdpi.com/2076-3417/15/3/1090
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