Macrophage fatty acid metabolism under chronic hypoxia shapes γδ T cell recruitment via CCL22

Macrophage fatty acid metabolism under chronic hypoxia shapes γδ T cell recruitment via CCL22

Summary: Hypoxia in solid tumors is associated with poor outcomes because of metabolic adaptations that support tumor cell survival and alter immune cell function. However, the metabolic and phenotypic adaptations of macrophages (MФs) to chronic hypoxia (CH) remain unclear. This study identifies imp...

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Main Authors: Vanesa M. Guerrero Ruiz, Aya Khabaza, Rebekka Bauer, Blerina Aliraj, Siavash Mansouri, Sofie P. Meyer, Megan A. Palmer, Hauke Winter, Laura V. Klotz, Mohammed A.F. Elewa, Ivan M. Kur, Carlo Angioni, Rahmat Mojaradfar, Lisa Hahnefeld, Rajkumar Savai, Dominik Fuhrmann, Andreas Weigert, Bernhard Brüne
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Human metabolism
Immune response
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012866
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http://www.sciencedirect.com/science/article/pii/S2589004225012866

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