Fisetin limits Chikungunya virus-induced apoptosis hallmarks in hepatocellular carcinoma cells

Fisetin limits Chikungunya virus-induced apoptosis hallmarks in hepatocellular carcinoma cells

Abstract The study investigated the protective effects of fisetin on chikungunya virus (CHIKV)-induced apoptosis hallmarks in Huh7 cells. Fisetin significantly reduced CHIKV RNA levels and viral infectivity, outperforming Z-VAD-FMK and cisplatin. At 30 µM, fisetin markedly decreased (by > 90%) th...

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Bibliographic Details
Main Authors: Rafidah Lani, Pouya Hassandarvish, Sazaly AbuBakar
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Apoptosis
Chikungunya
Flavonoids
Fisetin
Antiviral
Cytoprotective
Online Access:https://doi.org/10.1038/s41598-025-09213-6
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https://doi.org/10.1038/s41598-025-09213-6

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