Development and Optimization of Chitosan-Ascorbate-Based Mucoadhesive Films for Buccal Delivery of Captopril

Development and Optimization of Chitosan-Ascorbate-Based Mucoadhesive Films for Buccal Delivery of Captopril

<b>Background:</b> Captopril (CAP), an angiotensin-converting enzyme inhibitor (ACEI), is widely prescribed for managing hypertension, heart failure, and related conditions. When administered orally, CAP undergoes hepatic metabolism, resulting in a bioavailability of 60–75%. However, to...

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Main Authors: Krisztián Pamlényi, Hala Rayya, Alharith A. A. Hassan, Orsolya Jójárt-Laczkovich, Tamás Sovány, Klára Pintye-Hódi, Géza Regdon, Katalin Kristó
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
Subjects:
buccal drug delivery system
captopril
chitosan-ascorbate
DoE
factorial design
hypertension crisis
Online Access:https://www.mdpi.com/1999-4923/17/4/401
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