Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia
Vascular dementia (VaD) is a neurodegenerative disorder characterized by chronic oxygen insufficiency, leading to the generation of oxygen-free radicals, inflammatory responses, disturbances in iron metabolism, lipid peroxidation, and other pathological changes that disrupt intracellular homeostasis...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnmol.2025.1585079/full |
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| author | Xin-yi Zou Luo-yang Cai Jin Zhang Ying Yuan Jie Song Jie Song Zhao-duan Hu Zhao-duan Hu Zhao-duan Hu Xiao-feng Ruan Xiao-feng Ruan Rui Peng Rui Peng Rui Peng Xiao-ming Zhang Xiao-ming Zhang Xiao-ming Zhang Xiao-ming Zhang |
| author_facet | Xin-yi Zou Luo-yang Cai Jin Zhang Ying Yuan Jie Song Jie Song Zhao-duan Hu Zhao-duan Hu Zhao-duan Hu Xiao-feng Ruan Xiao-feng Ruan Rui Peng Rui Peng Rui Peng Xiao-ming Zhang Xiao-ming Zhang Xiao-ming Zhang Xiao-ming Zhang |
| author_sort | Xin-yi Zou |
| collection | DOAJ |
| description | Vascular dementia (VaD) is a neurodegenerative disorder characterized by chronic oxygen insufficiency, leading to the generation of oxygen-free radicals, inflammatory responses, disturbances in iron metabolism, lipid peroxidation, and other pathological changes that disrupt intracellular homeostasis. These processes ultimately lead to neuronal death and cognitive dysfunction. Normal neurological functions depend on the capacity of the iron homeostatic system to regulate the balance of oxidative states. Imbalances in iron metabolism render nerve cells highly susceptible to cell death induced by iron accumulation. Ferroptosis is a process in which iron catalyzes the peroxidation of unsaturated fatty acid-rich lipids, with ferrous iron or lipoxygenase acting as catalysts and ultimately resulting in cellular demise. Heme oxygenase-1 (HO-1) is a critical enzyme involved in the cellular response to oxidative stress and is essential for regulating signaling pathways linked to iron-mediated cell death. It protects neuronal cells by mitigating oxidative stress, reducing inflammation, and enhancing mitochondrial function, thereby alleviating cerebrovascular injury and slowing the progression of VaD. This paper provides a theoretical framework for understanding and potentially treating VaD-related neuronal injury through the investigation of ferroptosis mechanisms, the biological functions of HO-1, and its role in regulating ferroptosis. |
| format | Article |
| id | doaj-art-bcc3b5e4822d47a4aeb2255605f994bc |
| institution | OA Journals |
| issn | 1662-5099 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj-art-bcc3b5e4822d47a4aeb2255605f994bc2025-08-20T02:24:14ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992025-06-011810.3389/fnmol.2025.15850791585079Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementiaXin-yi Zou0Luo-yang Cai1Jin Zhang2Ying Yuan3Jie Song4Jie Song5Zhao-duan Hu6Zhao-duan Hu7Zhao-duan Hu8Xiao-feng Ruan9Xiao-feng Ruan10Rui Peng11Rui Peng12Rui Peng13Xiao-ming Zhang14Xiao-ming Zhang15Xiao-ming Zhang16Xiao-ming Zhang17College of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaCollege of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaCollege of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaHubei Shizhen Laboratory, Wuhan, ChinaCollege of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaHubei Shizhen Laboratory, Wuhan, ChinaCollege of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaHubei Shizhen Laboratory, Wuhan, ChinaSub-Health Institute, Hubei University of Chinese Medicine, Wuhan, ChinaCollege of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaHubei Shizhen Laboratory, Wuhan, ChinaCollege of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaHubei Shizhen Laboratory, Wuhan, ChinaSub-Health Institute, Hubei University of Chinese Medicine, Wuhan, ChinaCollege of Acupuncture-Moxibustion and Orthopedics, Hubei University of Chinese Medicine, Wuhan, ChinaHubei Shizhen Laboratory, Wuhan, ChinaSub-Health Institute, Hubei University of Chinese Medicine, Wuhan, ChinaHubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, ChinaVascular dementia (VaD) is a neurodegenerative disorder characterized by chronic oxygen insufficiency, leading to the generation of oxygen-free radicals, inflammatory responses, disturbances in iron metabolism, lipid peroxidation, and other pathological changes that disrupt intracellular homeostasis. These processes ultimately lead to neuronal death and cognitive dysfunction. Normal neurological functions depend on the capacity of the iron homeostatic system to regulate the balance of oxidative states. Imbalances in iron metabolism render nerve cells highly susceptible to cell death induced by iron accumulation. Ferroptosis is a process in which iron catalyzes the peroxidation of unsaturated fatty acid-rich lipids, with ferrous iron or lipoxygenase acting as catalysts and ultimately resulting in cellular demise. Heme oxygenase-1 (HO-1) is a critical enzyme involved in the cellular response to oxidative stress and is essential for regulating signaling pathways linked to iron-mediated cell death. It protects neuronal cells by mitigating oxidative stress, reducing inflammation, and enhancing mitochondrial function, thereby alleviating cerebrovascular injury and slowing the progression of VaD. This paper provides a theoretical framework for understanding and potentially treating VaD-related neuronal injury through the investigation of ferroptosis mechanisms, the biological functions of HO-1, and its role in regulating ferroptosis.https://www.frontiersin.org/articles/10.3389/fnmol.2025.1585079/fullheme oxygenase 1ferroptosisvascular dementiaoxidative stresslipid peroxidation |
| spellingShingle | Xin-yi Zou Luo-yang Cai Jin Zhang Ying Yuan Jie Song Jie Song Zhao-duan Hu Zhao-duan Hu Zhao-duan Hu Xiao-feng Ruan Xiao-feng Ruan Rui Peng Rui Peng Rui Peng Xiao-ming Zhang Xiao-ming Zhang Xiao-ming Zhang Xiao-ming Zhang Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia Frontiers in Molecular Neuroscience heme oxygenase 1 ferroptosis vascular dementia oxidative stress lipid peroxidation |
| title | Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia |
| title_full | Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia |
| title_fullStr | Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia |
| title_full_unstemmed | Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia |
| title_short | Mechanism of heme oxygenase-1 regulation of ferroptosis in vascular dementia |
| title_sort | mechanism of heme oxygenase 1 regulation of ferroptosis in vascular dementia |
| topic | heme oxygenase 1 ferroptosis vascular dementia oxidative stress lipid peroxidation |
| url | https://www.frontiersin.org/articles/10.3389/fnmol.2025.1585079/full |
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