Brolucizumab for the Treatment of Diabetic Macular Edema: An Optical Coherence Tomography-Based Analysis
<b>Objectives</b>: The objectives of this study were to evaluate the structural and functional outcomes after the loading phase with brolucizumab in switched patients with diabetic macular edema (DME) and to identify potential predictive biomarkers of treatment response. <b>Methods...
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MDPI AG
2024-12-01
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| author | Marco R. Pastore Serena Milan Stefano Gouigoux Olimpia Colombo Silvia Rinaldi Gabriella Cirigliano Daniele Tognetto |
| author_facet | Marco R. Pastore Serena Milan Stefano Gouigoux Olimpia Colombo Silvia Rinaldi Gabriella Cirigliano Daniele Tognetto |
| author_sort | Marco R. Pastore |
| collection | DOAJ |
| description | <b>Objectives</b>: The objectives of this study were to evaluate the structural and functional outcomes after the loading phase with brolucizumab in switched patients with diabetic macular edema (DME) and to identify potential predictive biomarkers of treatment response. <b>Methods</b>: A total of 28 eyes with DME, switched to brolucizumab, were retrospectively reviewed. Main outcomes during the follow-up period, up to 6 weeks after the fifth injection, included changes in best-corrected visual acuity (BCVA), central subfield thickness (CST), macular volume, subfoveal choroidal thickness, intraretinal and subretinal fluid (IRF and SRF), cyst dimension including maximal horizontal cyst diameter (MHCD), maximal vertical cyst diameter (MVCD), width-to-height ratio (WHR), foveal avascular zone (FAZ) dimension, and vessel density (VD). <b>Results</b>: At the last follow-up, BCVA was significantly improved (<i>p</i> = 0.003). Significant reduction of CST was demonstrated after each injection time point (<i>p</i> < 0.05), and a dry macula was detected in 64.3% of patients at the last follow-up. The WHR was 1.23 ± 0.46, and a negative correlation to final CST (<i>p</i> < 0.0001) was found. In FAZ and VD analysis, no significant variation was detected. At the last disease activity assessment, the treatment regimen was q12 in 64% of patients. <b>Conclusions</b>: Brolucizumab leads to anatomical and functional improvements in switched eyes affected by DME. WHR may represent a predictive biomarker of treatment response. |
| format | Article |
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| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-bcb8bdc3e40c46be8859f9503cd52e152024-12-27T14:20:58ZengMDPI AGDiagnostics2075-44182024-12-011424285810.3390/diagnostics14242858Brolucizumab for the Treatment of Diabetic Macular Edema: An Optical Coherence Tomography-Based AnalysisMarco R. Pastore0Serena Milan1Stefano Gouigoux2Olimpia Colombo3Silvia Rinaldi4Gabriella Cirigliano5Daniele Tognetto6Eye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, 34127 Trieste, ItalyEye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, 34127 Trieste, ItalyEye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, 34127 Trieste, ItalyEye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, 34127 Trieste, ItalyEye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, 34127 Trieste, ItalyEye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, 34127 Trieste, ItalyEye Clinic, Department of Medical, Surgical Sciences and Health, University of Trieste, 34127 Trieste, Italy<b>Objectives</b>: The objectives of this study were to evaluate the structural and functional outcomes after the loading phase with brolucizumab in switched patients with diabetic macular edema (DME) and to identify potential predictive biomarkers of treatment response. <b>Methods</b>: A total of 28 eyes with DME, switched to brolucizumab, were retrospectively reviewed. Main outcomes during the follow-up period, up to 6 weeks after the fifth injection, included changes in best-corrected visual acuity (BCVA), central subfield thickness (CST), macular volume, subfoveal choroidal thickness, intraretinal and subretinal fluid (IRF and SRF), cyst dimension including maximal horizontal cyst diameter (MHCD), maximal vertical cyst diameter (MVCD), width-to-height ratio (WHR), foveal avascular zone (FAZ) dimension, and vessel density (VD). <b>Results</b>: At the last follow-up, BCVA was significantly improved (<i>p</i> = 0.003). Significant reduction of CST was demonstrated after each injection time point (<i>p</i> < 0.05), and a dry macula was detected in 64.3% of patients at the last follow-up. The WHR was 1.23 ± 0.46, and a negative correlation to final CST (<i>p</i> < 0.0001) was found. In FAZ and VD analysis, no significant variation was detected. At the last disease activity assessment, the treatment regimen was q12 in 64% of patients. <b>Conclusions</b>: Brolucizumab leads to anatomical and functional improvements in switched eyes affected by DME. WHR may represent a predictive biomarker of treatment response.https://www.mdpi.com/2075-4418/14/24/2858optical coherence tomographyretinal diseasesspectral-domain optical coherence tomographybrolucizumabdiabetic macular edemaintravitreal injection |
| spellingShingle | Marco R. Pastore Serena Milan Stefano Gouigoux Olimpia Colombo Silvia Rinaldi Gabriella Cirigliano Daniele Tognetto Brolucizumab for the Treatment of Diabetic Macular Edema: An Optical Coherence Tomography-Based Analysis Diagnostics optical coherence tomography retinal diseases spectral-domain optical coherence tomography brolucizumab diabetic macular edema intravitreal injection |
| title | Brolucizumab for the Treatment of Diabetic Macular Edema: An Optical Coherence Tomography-Based Analysis |
| title_full | Brolucizumab for the Treatment of Diabetic Macular Edema: An Optical Coherence Tomography-Based Analysis |
| title_fullStr | Brolucizumab for the Treatment of Diabetic Macular Edema: An Optical Coherence Tomography-Based Analysis |
| title_full_unstemmed | Brolucizumab for the Treatment of Diabetic Macular Edema: An Optical Coherence Tomography-Based Analysis |
| title_short | Brolucizumab for the Treatment of Diabetic Macular Edema: An Optical Coherence Tomography-Based Analysis |
| title_sort | brolucizumab for the treatment of diabetic macular edema an optical coherence tomography based analysis |
| topic | optical coherence tomography retinal diseases spectral-domain optical coherence tomography brolucizumab diabetic macular edema intravitreal injection |
| url | https://www.mdpi.com/2075-4418/14/24/2858 |
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