Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity

Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity

Abstract Systemic lipid homeostasis requires hepatic autophagy, a major cellular program for intracellular fat recycling. Here, we find melanocortin 3 receptor (MC3R) regulates hepatic autophagy in addition to its previously established CNS role in systemic energy partitioning and puberty. Mice with...

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Main Authors: Tushar P. Patel, Joo Yun Jun, Arnold Y. Seo, Noah J. Levi, Diana M. Elizondo, Jocelyn Chen, Adrian M. Wong, Nicol Tugarinov, Elizabeth K. Altman, Daniel B. Gehle, Sun Min Jung, Pooja Patel, Mark Ericson, Carrie Haskell-Luevano, Tamar C. Demby, Antony Cougnoux, Anna Wolska, Jack A. Yanovski
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56936-1
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https://doi.org/10.1038/s41467-025-56936-1

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