Cell cycle-dependent induction of homologous recombination by a tightly regulated I-SceI fusion protein.

Double-strand break repair is executed by two major repair pathways: non-homologous end joining (NHEJ) and homologous recombination (HR). Whereas NHEJ contributes to the repair of ionizing radiation (IR)-induced double strand breaks (DSBs) throughout the cell cycle, HR acts predominantly during the...

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Bibliographic Details
Main Authors: Andrea Hartlerode, Shobu Odate, Inbo Shim, Jenifer Brown, Ralph Scully
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-03-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016501&type=printable
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