A phase II trial of the epothilone B analog ixabepilone (BMS-247550) in patients with metastatic melanoma.

A phase II trial of the epothilone B analog ixabepilone (BMS-247550) in patients with metastatic melanoma.

<h4>Background</h4>Ixabepilone (BMS-247550), an epothilone B analog, is a microtubule stabilizing agent which has shown activity in several different tumor types and preclinical models in melanoma. In an open label, one-arm, multi-center phase II trial the efficacy and toxicity of this e...

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Main Authors: Patrick A Ott, Anne Hamilton, Amanda Jones, Naomi Haas, Tsiporah Shore, Sandra Liddell, Paul J Christos, L Austin Doyle, Michael Millward, Franco M Muggia, Anna C Pavlick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008714&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008714&type=printable

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