Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential

Engineering FcRn binding kinetics dramatically extends antibody serum half-life and enhances therapeutic potential

Abstract Background Optimizing the IgG Fc domain for neonatal Fc receptor (FcRn) binding is crucial for enhancing antibody pharmacokinetics. The prolonged serum half-life of IgG antibody is governed by its pH-dependent interaction with FcRn, enabling efficient binding at acidic endosomal pH, intrace...

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Bibliographic Details
Main Authors: Sanghwan Ko, Migyeong Jo, Munsu Kyung, Wonju Lee, Woo Hyung Ko, Jung-Hyun Na, Youn Seo Chun, Byoung Joon Ko, Sang Taek Jung
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Biological Engineering
Subjects:
Therapeutic antibody
FcRn
pH-dependent FcRn binding kinetics
Endogenous IgG competition
Serum half-life
Complement-dependent cytotoxicity
Online Access:https://doi.org/10.1186/s13036-025-00506-y
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https://doi.org/10.1186/s13036-025-00506-y

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