Antimalarial compounds exhibit variant- and cell-type-specific activity against SARS-CoV-2 isolated in Panama

Antimalarial compounds exhibit variant- and cell-type-specific activity against SARS-CoV-2 isolated in Panama

BackgroundThis study evaluates the antiviral activity of antimalarial compounds against SARS-CoV-2 variants isolated in Panama (2020–2022).MethodsFor this purpose, we conducted a series of in vitro assays in two host mammalian cell systems, Vero-E6 and Calu-3 cells, to assess the antiviral activity...

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Bibliographic Details
Main Authors: Mario Quijada, Marlene Castillo-Bultron, Yamilka Díaz, Yaneth Pitti, Danilo Franco, Carolina De La Guardia, Dalkiria Campos, Eduardo Cornejo, Marlon Núñez, Lariza Mendoza, Sandra López-Vergès, Ariel H. Magallon-Tejada, Nicanor Obaldia
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
COVID-19
SARS-CoV-2 variants
in vitro
antimalarials
antivirals
Vero-E6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1537053/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1537053/full

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