E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult

E. coli genetically modified for purine nucleobase release promotes butyrate generation and colonic wound healing during DSS insult

The gut microbiota transforms energy stored as undigestible carbohydrates into a remarkable number of metabolites that fuel intestinal bacterial communities and the host tissue. Colonic epithelial cells at the microbiota–host interface depend upon such microbiota-derived metabolites (MDMs) to satisf...

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Bibliographic Details
Main Authors: J. Scott Lee, Daniel J. Kao, Corey S. Worledge, Zachary F. Villamaria, Ruth X. Wang, Nichole M. Welch, Rachael E. Kostelecky, Sean P. Colgan
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
Microbiota-derived metabolites
butyrate
hypoxanthine
purines
energy metabolism
epithelial barrier
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2490211
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https://www.tandfonline.com/doi/10.1080/19490976.2025.2490211

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