Autophagy extends lifespan via vacuolar acidification

Autophagy extends lifespan via vacuolar acidification

Methionine restriction (MetR) is one of the rare regimes that prolongs lifespan across species barriers. Using a yeast model, we recently demonstrated that this lifespan extension is promoted by autophagy, which in turn requires vacuolar acidification. Our study is the first to place autophagy as on...

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Main Authors: Christoph Ruckenstuhl, Christine Netzberger, Iryna Entfellner, Didac Carmona-Gutierrez, Thomas Kickenweiz, Slaven Stekovic, Christina Gleixner, Christian Schmid, Lisa Klug, Ivan Hajnal, Alice G. Sorgo, Tobias Eisenberg, Sabrina Büttner, Guillermo Marino, Rafal Koziel, Christoph Magnes, Frank Sinner, Thomas R. Pieber, Pidder Jansen-Dürr, Kai-Uwe Fröhlich, Guido Kroemer, Frank Madeo
Format: Article
Language:English
Published: Shared Science Publishers OG 2014-05-01
Series:Microbial Cell
Subjects:
autophagy
methionine restriction
longevity
chronological lifespan
dietary restriction
vacuole
lysosome
acidification
Online Access:http://microbialcell.com/researcharticles/autophagy-extends-lifespan-via-vacuolar-acidification/
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http://microbialcell.com/researcharticles/autophagy-extends-lifespan-via-vacuolar-acidification/

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