SILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor sensitive and resistant melanoma cells

SILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor sensitive and resistant melanoma cells

BackgroundThe immunopeptidome is constantly monitored by T cells to detect foreign or aberrant HLA peptides. It is highly dynamic and reflects the current cellular state, enabling the immune system to recognize abnormal cellular conditions, such as those present in cancer cells. To precisely determi...

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Bibliographic Details
Main Authors: Melissa Bernhardt, Anne Rech, Marion Berthold, Melina Lappe, Jan-Niklas Herbel, Florian Erhard, Annette Paschen, Bastian Schilling, Andreas Schlosser
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
mass spectrometry
stable isotope labeling
HLA-I peptides
T-cell epitopes
de novo peptide sequencing
cryptic HLA peptides
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490821/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1490821/full

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