Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats

Trace amine-associated receptor 1 agonist reduces aggression in brain serotonin-deficient tryptophan hydroxylase 2 knockout rats

IntroductionAggression and self-harm disproportionately occur in youths preoccupied with social status tracking. These pathological conditions are linked to a serotonin (5-HT) deficit in the brain. Ablation of 5-HT biosynthesis by tryptophan hydroxylase 2 knockout (TPH2-KO) increases aggression in r...

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Main Authors: Ilya S. Zhukov, Yazen Alnefeesi, Natalya A. Krotova, Vsevolod V. Nemets, Konstantin A. Demin, Marina N. Karpenko, Evgeny A. Budygin, Evgeny V. Kanov, Allan V. Kalueff, Petr D. Shabanov, Michael Bader, Natalia Alenina, Raul R. Gainetdinov
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Psychiatry
Subjects:
serotonin
TPH2
5HT
TAAR1
aggression
RO5263397
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1484925/full
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https://www.frontiersin.org/articles/10.3389/fpsyt.2024.1484925/full

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