Cellular Reprogramming toward the Erythroid Lineage
Haemoglobinopathies such as thalassaemia and sickle cell disease present a major health burden. Currently, the main forms of treatment for these diseases are packed red blood cell transfusions and the administration of drugs which act to nonspecifically reactivate the production of foetal haemoglobi...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2011/501464 |
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| _version_ | 1832553354899750912 |
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| author | Laura J. Norton Alister P. W. Funnell Richard C. M. Pearson Merlin Crossley |
| author_facet | Laura J. Norton Alister P. W. Funnell Richard C. M. Pearson Merlin Crossley |
| author_sort | Laura J. Norton |
| collection | DOAJ |
| description | Haemoglobinopathies such as thalassaemia and sickle cell disease present a major health burden. Currently, the main forms of treatment for these diseases are packed red blood cell transfusions and the administration of drugs which act to nonspecifically reactivate the production of foetal haemoglobin. These treatments are ongoing throughout the life of the patient and are associated with a number of risks, such as limitations in available blood for transfusion, infections, iron overload, immune rejection, and side effects associated with the drug treatments. The field of cellular reprogramming has advanced significantly in the last few years and has recently culminated in the successful production of erythrocytes in culture. This paper will discuss cellular reprogramming and its potential relevance to the treatment of haemoglobinopathies. |
| format | Article |
| id | doaj-art-bc1456c5e68640488a5ed89db7907bd5 |
| institution | Kabale University |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-bc1456c5e68640488a5ed89db7907bd52025-02-03T05:54:20ZengWileyInternational Journal of Cell Biology1687-88761687-88842011-01-01201110.1155/2011/501464501464Cellular Reprogramming toward the Erythroid LineageLaura J. Norton0Alister P. W. Funnell1Richard C. M. Pearson2Merlin Crossley3School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, AustraliaHaemoglobinopathies such as thalassaemia and sickle cell disease present a major health burden. Currently, the main forms of treatment for these diseases are packed red blood cell transfusions and the administration of drugs which act to nonspecifically reactivate the production of foetal haemoglobin. These treatments are ongoing throughout the life of the patient and are associated with a number of risks, such as limitations in available blood for transfusion, infections, iron overload, immune rejection, and side effects associated with the drug treatments. The field of cellular reprogramming has advanced significantly in the last few years and has recently culminated in the successful production of erythrocytes in culture. This paper will discuss cellular reprogramming and its potential relevance to the treatment of haemoglobinopathies.http://dx.doi.org/10.1155/2011/501464 |
| spellingShingle | Laura J. Norton Alister P. W. Funnell Richard C. M. Pearson Merlin Crossley Cellular Reprogramming toward the Erythroid Lineage International Journal of Cell Biology |
| title | Cellular Reprogramming toward the Erythroid Lineage |
| title_full | Cellular Reprogramming toward the Erythroid Lineage |
| title_fullStr | Cellular Reprogramming toward the Erythroid Lineage |
| title_full_unstemmed | Cellular Reprogramming toward the Erythroid Lineage |
| title_short | Cellular Reprogramming toward the Erythroid Lineage |
| title_sort | cellular reprogramming toward the erythroid lineage |
| url | http://dx.doi.org/10.1155/2011/501464 |
| work_keys_str_mv | AT laurajnorton cellularreprogrammingtowardtheerythroidlineage AT alisterpwfunnell cellularreprogrammingtowardtheerythroidlineage AT richardcmpearson cellularreprogrammingtowardtheerythroidlineage AT merlincrossley cellularreprogrammingtowardtheerythroidlineage |