Impact of POU3F4 mutation on cochlear development and auditory function

Impact of POU3F4 mutation on cochlear development and auditory function

Abstract Background Hearing loss, a major public health issue, affects 1.33 per 1,000 live births worldwide. Genetic factors contribute to over half of congenital cases, with X-linked inheritance accounting for 1–5%. POU3F4 mutations are associated with approximately 50% of X-linked non-syndrome hea...

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Main Authors: Jiong Dang, Panpan Bian, Chao Chen, Chi Chen, Wenqi Shan, Luhang Cai, Yong Li, Huan Tan, Baicheng Xu, Minxin Guan, Yufen Guo
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cell Communication and Signaling
Subjects:
POU3F4
Cochlear development
Hearing loss
Mitochondrial dysfunction
Apoptosis
Oxidative phosphorylation
Online Access:https://doi.org/10.1186/s12964-025-02133-y
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https://doi.org/10.1186/s12964-025-02133-y

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