Enhanced Age-Dependent Motor Impairment in Males of <i>Drosophila melanogaster</i> Modeling Spinocerebellar Ataxia Type 1 Is Linked to Dysregulation of a Matrix Metalloproteinase

Enhanced Age-Dependent Motor Impairment in Males of <i>Drosophila melanogaster</i> Modeling Spinocerebellar Ataxia Type 1 Is Linked to Dysregulation of a Matrix Metalloproteinase

Over the past two decades, <i>Drosophila melanogaster</i> has proven to be successful in modeling the polyglutamine (polyQ) (caused by CAG repeats) family of neurodegenerative disorders, including the faithful recapitulation of pathological features such as polyQ length-dependent formati...

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Bibliographic Details
Main Authors: Emma M. Palmer, Caleb A. Snoddy, Peyton M. York, Sydney M. Davis, Madelyn F. Hunter, Natraj Krishnan
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Biology
Subjects:
ataxin1
<i>Drosophila melanogaster</i>
lifespan
matrix metalloproteinase
polyglutamine
Online Access:https://www.mdpi.com/2079-7737/13/11/854
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