Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort Analysis
Background. We analyzed the incidence, risk factors, and prognosis of acute kidney injury (AKI) in a cohort of patients undergoing major abdominal surgery. Methods. A total of 450 patients were retrospectively studied. AKI was defined by an increase in serum creatinine (SCr) ≥ 0.3 mg/dl or by an in...
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| Language: | English |
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Wiley
2014-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2014/132175 |
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| author | Catarina Teixeira Rosário Rosa Natacha Rodrigues Inês Mendes Lígia Peixoto Sofia Dias Maria João Melo Marta Pereira Henrique Bicha Castelo José António Lopes |
| author_facet | Catarina Teixeira Rosário Rosa Natacha Rodrigues Inês Mendes Lígia Peixoto Sofia Dias Maria João Melo Marta Pereira Henrique Bicha Castelo José António Lopes |
| author_sort | Catarina Teixeira |
| collection | DOAJ |
| description | Background. We analyzed the incidence, risk factors, and prognosis of acute kidney injury (AKI) in a cohort of patients undergoing major abdominal surgery. Methods. A total of 450 patients were retrospectively studied. AKI was defined by an increase in serum creatinine (SCr) ≥ 0.3 mg/dl or by an increase in SCr ≥ 50% and/or by a decrease in urine output to 0.5 ml/kg/hour for 6 hours, in the first 48 hours after surgery. Logistic regression method was used to determine predictors of AKI and in-hospital mortality. A two-tailed P value <0.05 was considered significant. Results. One hundred one patients (22.4%) had postoperative AKI. Age (adjusted odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01–1.05), nonrenal Revised Cardiac Risk Index score (adjusted OR 1.9, 95% CI 1.3–3.1, P=0.003), intraoperative erythrocytes transfusions (adjusted OR 2.2, 95% CI 1.4–3.5, P <.0001), and nonrenal Simplified Acute Physiology Score II (adjusted OR 1.03, 95% CI 1.01–1.06, P=0.0191) were associated with postoperative AKI. AKI was associated with increased in-hospital mortality (20.8% versus 2.3%, P <.0001; unadjusted OR 11.2, 95% CI 4.8–26.2, P <.0001; adjusted OR 3.7, 95% CI 1.2–11.7, P=0.024). Conclusion. AKI was common in patients undergoing major abdominal surgery and was associated with in-hospital mortality. |
| format | Article |
| id | doaj-art-bbe6bcbc08d6421899ad10bc404e34a0 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-bbe6bcbc08d6421899ad10bc404e34a02025-02-03T05:50:23ZengWileyCritical Care Research and Practice2090-13052090-13132014-01-01201410.1155/2014/132175132175Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort AnalysisCatarina Teixeira0Rosário Rosa1Natacha Rodrigues2Inês Mendes3Lígia Peixoto4Sofia Dias5Maria João Melo6Marta Pereira7Henrique Bicha Castelo8José António Lopes9Service of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalService of Surgery II, Department of Surgery, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalService of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalService of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalService of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalService of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalService of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalService of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalService of Surgery II, Department of Surgery, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalService of Nephrology and Renal Transplantation, Department of Medicine, Centro Hospitalar Lisboa Norte, EPE, Avenue Prof. Egas Moniz, 1649-035 Lisboa, PortugalBackground. We analyzed the incidence, risk factors, and prognosis of acute kidney injury (AKI) in a cohort of patients undergoing major abdominal surgery. Methods. A total of 450 patients were retrospectively studied. AKI was defined by an increase in serum creatinine (SCr) ≥ 0.3 mg/dl or by an increase in SCr ≥ 50% and/or by a decrease in urine output to 0.5 ml/kg/hour for 6 hours, in the first 48 hours after surgery. Logistic regression method was used to determine predictors of AKI and in-hospital mortality. A two-tailed P value <0.05 was considered significant. Results. One hundred one patients (22.4%) had postoperative AKI. Age (adjusted odds ratio (OR) 1.02, 95% confidence interval (CI) 1.01–1.05), nonrenal Revised Cardiac Risk Index score (adjusted OR 1.9, 95% CI 1.3–3.1, P=0.003), intraoperative erythrocytes transfusions (adjusted OR 2.2, 95% CI 1.4–3.5, P <.0001), and nonrenal Simplified Acute Physiology Score II (adjusted OR 1.03, 95% CI 1.01–1.06, P=0.0191) were associated with postoperative AKI. AKI was associated with increased in-hospital mortality (20.8% versus 2.3%, P <.0001; unadjusted OR 11.2, 95% CI 4.8–26.2, P <.0001; adjusted OR 3.7, 95% CI 1.2–11.7, P=0.024). Conclusion. AKI was common in patients undergoing major abdominal surgery and was associated with in-hospital mortality.http://dx.doi.org/10.1155/2014/132175 |
| spellingShingle | Catarina Teixeira Rosário Rosa Natacha Rodrigues Inês Mendes Lígia Peixoto Sofia Dias Maria João Melo Marta Pereira Henrique Bicha Castelo José António Lopes Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort Analysis Critical Care Research and Practice |
| title | Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort Analysis |
| title_full | Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort Analysis |
| title_fullStr | Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort Analysis |
| title_full_unstemmed | Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort Analysis |
| title_short | Acute Kidney Injury after Major Abdominal Surgery: A Retrospective Cohort Analysis |
| title_sort | acute kidney injury after major abdominal surgery a retrospective cohort analysis |
| url | http://dx.doi.org/10.1155/2014/132175 |
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