Multicellular Cancer-Stroma Spheres (CSS) for In Vitro Assessment of CAR-T Cell-Associated Toxicity

Multicellular Cancer-Stroma Spheres (CSS) for In Vitro Assessment of CAR-T Cell-Associated Toxicity

CAR-T therapy has revolutionized the field of oncology, offering a promising treatment option for cancer patients. However, the significant morbidity associated with therapy-related toxicity presents a major challenge to its widespread use. Despite extensive research into the underlying mechanisms o...

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Bibliographic Details
Main Authors: Aigul R. Rakhmatullina, Mariya A. Zolotykh, Yuliya V. Filina, Aigul Kh. Valiullina, Ekaterina A. Zmievskaya, Dina U. Gafurbaeva, Aisylu R. Sagdeeva, Emil R. Bulatov, Albert A. Rizvanov, Regina R. Miftakhova
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Cells
Subjects:
CAR-T therapy
cytokine release syndrome
immune effector cell-associated neurotoxicity syndrome
cancer-stroma spheres
mesenchymal stem cell
IL-8
Online Access:https://www.mdpi.com/2073-4409/13/22/1892
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