Mannich Base Derived from Lawsone Inhibits PKM2 and Induces Neoplastic Cell Death

Mannich Base Derived from Lawsone Inhibits PKM2 and Induces Neoplastic Cell Death

<b>Background/Objectives:</b> Pyruvate kinase M2, a central regulator of cancer cell metabolism, has garnered significant attention as a promising target for disrupting the metabolic adaptability of tumor cells. This study explores the potential of the Mannich base derived from lawsone (...

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Main Authors: Lucas Rubini-Dias, Tácio V. A. Fernandes, Michele P. de Souza, Déborah Hottz, Afonso T. Arruda, Amanda de A. Borges, Gabriel Ouverney, Fernando de C. da Silva, Luana da S. M. Forezi, Gabriel Limaverde-Sousa, Bruno K. Robbs
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Biomedicines
Subjects:
oral squamous cell carcinoma
Mannich bases
M2-type pyruvate kinase
autophagy
molecular docking simulation
Online Access:https://www.mdpi.com/2227-9059/12/12/2916
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