Tissue distribution pharmacokinetics of intrathecal U1 adaptor oligonucleotide in mice

Tissue distribution pharmacokinetics of intrathecal U1 adaptor oligonucleotide in mice

U1 Adaptor is a novel gene-silencing technology, offering an innovative approach to target genes in the CNS for the treatment of diseases. Intrathecal delivery is a medically viable route of administration of CNS-bound nucleic acid drugs; therefore, it is important to investigate U1 Adaptor distribu...

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Bibliographic Details
Main Authors: Medha Satti, Kavita Prasad, Yash Patel, Demi Poulathas, Lawrence Walker, Esha Paghdal, Samuel Gunderson, Lei Yu
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Current Research in Pharmacology and Drug Discovery
Subjects:
U1 adaptors
Gene silencing
Central nervous system
Intrathecal administration
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2590257125000082
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