Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic Abscesses
Herpes simplex virus (HSV) hepatitis represents a rare complication of HSV infection, which can progress to acute liver failure and, in some cases, death. We describe an immunocompetent 67-year-old male who presented with one week of fever and abdominal pain. Computed tomography (CT) scan and magnet...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2016/8348172 |
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| author | Carrie Down Amit Mehta Gayle Salama Erika Hissong Russell Rosenblatt Michael Cantor David Helfgott Kristen Marks |
| author_facet | Carrie Down Amit Mehta Gayle Salama Erika Hissong Russell Rosenblatt Michael Cantor David Helfgott Kristen Marks |
| author_sort | Carrie Down |
| collection | DOAJ |
| description | Herpes simplex virus (HSV) hepatitis represents a rare complication of HSV infection, which can progress to acute liver failure and, in some cases, death. We describe an immunocompetent 67-year-old male who presented with one week of fever and abdominal pain. Computed tomography (CT) scan and magnetic resonance imaging (MRI) of the abdomen showed multiple bilobar hepatic lesions, some with rim enhancement, compatible with liver abscesses. Subsequent liver biopsy, however, revealed hepatocellular necrosis, HSV-type intranuclear inclusions, and immunostaining positive for herpes virus type 2 (HSV-2). Though initially treated with broad-spectrum antibiotics, following histologic diagnosis of HSV hepatitis, the patient was transitioned to intravenous acyclovir for four weeks and he achieved full clinical recovery. Given its high mortality and nonspecific presentation, one should consider HSV hepatitis in all patients with acute hepatitis with multifocal hepatic lesions of unknown etiology. Of special note, this is only the second reported case of HSV liver lesions mimicking pyogenic abscesses on CT and MRI. |
| format | Article |
| id | doaj-art-bbac51b42a064d5a859dc71d2b9feb44 |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-bbac51b42a064d5a859dc71d2b9feb442025-02-03T01:01:48ZengWileyCase Reports in Hepatology2090-65872090-65952016-01-01201610.1155/2016/83481728348172Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic AbscessesCarrie Down0Amit Mehta1Gayle Salama2Erika Hissong3Russell Rosenblatt4Michael Cantor5David Helfgott6Kristen Marks7Department of Medicine, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10065, USADepartment of Medicine, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10065, USADepartment of Radiology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10065, USADepartment of Pathology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10065, USADivision of Gastroenterology & Hepatology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10021, USADivision of Gastroenterology & Hepatology, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 10021, USADivision of Infectious Disease, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 100021, USADivision of Infectious Disease, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, NY 100021, USAHerpes simplex virus (HSV) hepatitis represents a rare complication of HSV infection, which can progress to acute liver failure and, in some cases, death. We describe an immunocompetent 67-year-old male who presented with one week of fever and abdominal pain. Computed tomography (CT) scan and magnetic resonance imaging (MRI) of the abdomen showed multiple bilobar hepatic lesions, some with rim enhancement, compatible with liver abscesses. Subsequent liver biopsy, however, revealed hepatocellular necrosis, HSV-type intranuclear inclusions, and immunostaining positive for herpes virus type 2 (HSV-2). Though initially treated with broad-spectrum antibiotics, following histologic diagnosis of HSV hepatitis, the patient was transitioned to intravenous acyclovir for four weeks and he achieved full clinical recovery. Given its high mortality and nonspecific presentation, one should consider HSV hepatitis in all patients with acute hepatitis with multifocal hepatic lesions of unknown etiology. Of special note, this is only the second reported case of HSV liver lesions mimicking pyogenic abscesses on CT and MRI.http://dx.doi.org/10.1155/2016/8348172 |
| spellingShingle | Carrie Down Amit Mehta Gayle Salama Erika Hissong Russell Rosenblatt Michael Cantor David Helfgott Kristen Marks Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic Abscesses Case Reports in Hepatology |
| title | Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic Abscesses |
| title_full | Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic Abscesses |
| title_fullStr | Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic Abscesses |
| title_full_unstemmed | Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic Abscesses |
| title_short | Herpes Simplex Virus Hepatitis in an Immunocompetent Host Resembling Hepatic Pyogenic Abscesses |
| title_sort | herpes simplex virus hepatitis in an immunocompetent host resembling hepatic pyogenic abscesses |
| url | http://dx.doi.org/10.1155/2016/8348172 |
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