Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

Protein kinase 2 of the giant sarcomeric protein UNC-89 regulates mitochondrial morphology and function

Abstract UNC-89 is a giant sarcomeric M-line protein required for sarcomere organization and optimal muscle function. UNC-89 contains two protein kinase domains, PK1 and PK2, separated by an elastic region. Here we show that PK2 is a canonical kinase expected to be catalytically active. C. elegans e...

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Main Authors: Yohei Matsunaga, Hiroshi Qadota, Nasab Ghazal, Leila Lesanpezeshki, Till Dorendorf, Jasmine C. Moody, Arnaud Ahier, Courtney J. Matheny, Siva A. Vanapalli, Steven Zuryn, Olga Mayans, Jennifer Q. Kwong, Guy M. Benian
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-07042-3
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https://doi.org/10.1038/s42003-024-07042-3

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