A new 3-arylbenzofuran derivative EIE-2 reestablishes Treg-dependent tolerance in rheumatoid arthritis by targeting on Syk induced mTOR and PKCθ imbalance

A new 3-arylbenzofuran derivative EIE-2 reestablishes Treg-dependent tolerance in rheumatoid arthritis by targeting on Syk induced mTOR and PKCθ imbalance

IntroductionDysfunctional self-tolerance is thought to play a crucial role in the onset of rheumatoid arthritis (RA) pathogenesis. Poorly functioning regulatory T cells (Tregs) lead to extreme situations where self-tolerance is robustly disrupted. However, there are many uncertainties regarding its...

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Bibliographic Details
Main Authors: Ping Li, Xin Yin, Xinzhu Wen, Xuyu Li, Yuqing Wang, Hongyan Zhan, Hanqing Che, Chunsuo Yao, Qi Hou, Ziqian Zhang, Ruifang Zheng, Mingbao Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
EIE-2
rheumatoid arthritis
Treg-dependent tolerance
Syk
PKCθ/mTOR
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524491/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1524491/full

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