Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion

Fibroblast growth factor receptor signaling modulates cholesterol storage in a SOAT1-dependent manner to promote mammary tumor cell invasion

Abstract Signaling by fibroblast growth factor receptors (FGFRs) is active in up to 85% of breast cancers and results in enhanced proliferation, migration, and invasion of tumor cells. Here, we show that FGFR signaling regulates cholesterol metabolism in breast cancer. Specifically, we demonstrate t...

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Bibliographic Details
Main Authors: Jennifer E. Tuokkola, Lyndsay E. Reese, Ying Wang, Christine H. O’Connor, Jillian G. VanTreeck, Annisa H. Rumahorbo, Kathryn L. Schwertfeger
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Breast Cancer Research
Subjects:
Triple-negative breast cancer
Fibroblast growth factor
Cholesterol metabolism
Cholesterol storage
Online Access:https://doi.org/10.1186/s13058-025-02084-9
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https://doi.org/10.1186/s13058-025-02084-9

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