Sex difference in BAT thermogenesis depends on PGC-1α–mediated phospholipid synthesis in mice

Sex difference in BAT thermogenesis depends on PGC-1α–mediated phospholipid synthesis in mice

Abstract Brown adipose tissue (BAT), a thermogenic tissue that plays an important role in systemic energy expenditure, has histological and functional sex differences. BAT thermogenic activity is higher in female mice than in male mice. However, the molecular mechanism underlying this functional sex...

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Main Authors: Akira Takeuchi, Kazutaka Tsujimoto, Jun Aoki, Kenji Ikeda, Nozomu Kono, Kuniyuki Kano, Yoshihiro Niitsu, Masato Horino, Kazunari Hara, Rei Okazaki, Ryo Kaneda, Masanori Murakami, Kumiko Shiba, Chikara Komiya, Junken Aoki, Tetsuya Yamada
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61219-w
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https://doi.org/10.1038/s41467-025-61219-w

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