Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation

Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation

Abstract Hormonal contraception exposes women to synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progesterone and progestins affect the breast epithelium is poorly understood because we lack adequate models to study this. We hypothesized t...

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Bibliographic Details
Main Authors: Marie Shamseddin, Fabio De Martino, Céline Constantin, Valentina Scabia, Anne‐Sophie Lancelot, Csaba Laszlo, Ayyakkannu Ayyannan, Laura Battista, Wassim Raffoul, Marie‐Christine Gailloud‐Matthieu, Philipp Bucher, Maryse Fiche, Giovanna Ambrosini, George Sflomos, Cathrin Brisken
Format: Article
Language:English
Published: Springer Nature 2021-05-01
Series:EMBO Molecular Medicine
Subjects:
androgen receptor signaling
breast cancer
hormonal contraception
progestins
xenografts
Online Access:https://doi.org/10.15252/emmm.202114314
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https://doi.org/10.15252/emmm.202114314

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