Estrogen receptor alpha dynamics and plasticity during endocrine resistance

Estrogen receptor alpha dynamics and plasticity during endocrine resistance

Abstract Background Breast cancer is subdivided into four distinct subtypes based on the status of hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2) as HER2−/HR+, HER2+/HR+, HER2+/HR− and HER2−/HR−. Among this, ERα positive breast cancer, even though they respond to endocrin...

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Main Authors: Aswathy Sivasailam, Kiran S. Kumar, Aparna Geetha Jayaprasad, Shine Varghese Jancy, Ashwathi Harikumar, P. S. Unnikrishnan, K. C. Sivakumar, P. J. Jain Tiffee, Aman Munirpasha Halikar, S. S. Nithin, Prakash R. Pillai, Shivanshu Kumar Tiwari, Vishnu S. Sanjeev, A. V. Surabhi, T. R. Santhoshkumar
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Biology Direct
Subjects:
Breast cancer
Estrogen receptor alpha (ERα)
Receptor heterogeneity
Endocrine resistance
Unfolded protein response
Tamoxifen
Online Access:https://doi.org/10.1186/s13062-025-00653-8
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https://doi.org/10.1186/s13062-025-00653-8

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