Multicomponent thiolactone-based ionizable lipid screening platform for efficient and tunable mRNA delivery to the lungs

Multicomponent thiolactone-based ionizable lipid screening platform for efficient and tunable mRNA delivery to the lungs

Abstract Ionizable lipids are essential components of lipid nanoparticles (LNPs) for efficient mRNA delivery. However, designing them for high protein expression, endosomal escape, and organ targeting is challenging due to complex structure-activity relationships. Here, we present a high-throughput...

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Main Authors: Álvaro Peña, Juan Heredero, Beatriz Blandín, Elena Mata, Diego De Miguel, Alfonso Toro, Teresa Alejo, Diego Casabona, Alexandre López, Ana Gallego-Lleyda, Esther Pérez-Herrán, Juan Martínez-Oliván, Javier Giménez-Warren
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01516-z
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https://doi.org/10.1038/s42004-025-01516-z

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