A subset of Orai1α and Orai1β subunits heteromerizes to form CRAC channels

A subset of Orai1α and Orai1β subunits heteromerizes to form CRAC channels

Abstract Background Ca2+ release-activated Ca2+ (CRAC) channels are highly Ca2+ selective plasma membrane channels formed by the hexameric assembly of Orai subunits, with a predominant role for Orai1. Two Orai1 variants have been identified, Orai1α, which comprises 301 amino acids, and a short varia...

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Main Authors: Jose J. Lopez, Isaac Jardín, Vanesa Jiménez-Velarde, Sandra Alvarado, Alvaro Macías-Díaz, Joel Nieto-Felipe, Francisco J. Martín-Romero, Tarik Smani, Juan A. Rosado
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Cell Communication and Signaling
Subjects:
Orai1α
Orai1β
Store-operated Ca2+ entry
Lipid rafts
Online Access:https://doi.org/10.1186/s12964-025-02271-3
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https://doi.org/10.1186/s12964-025-02271-3

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