Identification of DNA damage and repair gene-related markers in pancreatic ductal adenocarcinoma by single-cell and bulk RNA sequencing

Identification of DNA damage and repair gene-related markers in pancreatic ductal adenocarcinoma by single-cell and bulk RNA sequencing

Abstract Background The DNA damage response (DDR) has a major impact on the development and progression of pancreatic ductal adenocarcinoma (PDAC). Investigating biomarkers linked to the DDR may facilitate prognostic assessment and prediction of immunological characteristics for patients with PDAC....

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Bibliographic Details
Main Authors: Chaoyi Zhang, Rong Tang, Jianhui Yang, Yueyue Chen, Yangyi Li, Cong Zhou, Wei Wang, Xian-Jun Yu, Jin Xu
Format: Article
Language:English
Published: Springer 2025-04-01
Series:Discover Oncology
Subjects:
Pancreatic ductal adenocarcinoma
DNA damage- and repair-related genes
Survival
Chemotherapeutic response
Online Access:https://doi.org/10.1007/s12672-025-02293-w
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https://doi.org/10.1007/s12672-025-02293-w

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