Recapitulation of endochondral ossification by hPSC-derived SOX9 + sclerotomal progenitors

Recapitulation of endochondral ossification by hPSC-derived SOX9 + sclerotomal progenitors

Abstract Endochondral ossification generates most of the load-bearing bones, recapitulating it in human cells remains a challenge. Here, we report generation of SOX9 + sclerotomal progenitors (scl-progenitors), a mesenchymal precursor at the pre-condensation stage, from human pluripotent stem cells...

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Main Authors: Jingfei Xiong, Runxin Ma, Kun Xie, Ce Shan, Hanyi Chen, Yuqing Wang, Yuansong Liao, Yanhui Deng, Guogen Ye, Yifu Wang, Qing Zhu, Yunqiu Zhang, Haoyang Cai, Weihua Guo, Yike Yin, Zhonghan Li
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58122-9
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https://doi.org/10.1038/s41467-025-58122-9

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