S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling

S-propargyl-cysteine attenuates temporomandibular joint osteoarthritis by regulating macrophage polarization via Inhibition of JAK/STAT signaling

Abstract Background Temporomandibular joint osteoarthritis (TMJ-OA) is a disease characterized by cartilage degradation and synovial inflammation, with limited effective treatment currently. Synovial macrophage polarization is pivotal in TMJ-OA progression, making it a promising therapeutic aspect....

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Main Authors: Wenyi Cai, Antong Wu, Zhongxiao Lin, Wei Cao, Janak L. Pathak, Richard T. Jaspers, Rui Li, Xin Li, Kaihan Zheng, Yufu Lin, Na Zhou, Xin Zhang, Yizhun Zhu, Qingbin Zhang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Molecular Medicine
Subjects:
Temporomandibular joint osteoarthritis
S-propargyl-cysteine
Macrophage
JAK/STAT
Synovial
Hydrogen sulfide
Online Access:https://doi.org/10.1186/s10020-025-01186-6
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https://doi.org/10.1186/s10020-025-01186-6

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